h a l f b a k e r y"Put it on a plate, son. You'll enjoy it more."
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This is a male based form of birth control that could also
prevent birth defects and be used to have only
daughters.
Note, you know how on chromosome maps the like
chromosomes line up.
Well cohesin is like the rubber band that sorts the sister
chromatids during meiosis.
Any change to
the affinity of this protein to chromatids
causes them to sort the wrong way with 2^23 possible
recombinations during meiosis the odds of creating a
functional gamete are trillions to one.
When the scrambled gamete meets the egg there is an
absence of pregnancy
siRNA drugs could affect cohesin, as could little organic
molecules. They guy takes a pill, perhaps monthly, or
perhaps gets an implant (siRNA)
cohesin antibodies or a cohesin antibody producing virus
are technologies but iffy as cohesin is intracyte and away
from the circulatory system. A virus could produce siRNA
cohesin drugs though.
likewise a cohesin with stronger affinity could reduce
birth defects or be used to exclude the y chromosome to
produce only daughters
cohesin
http://www.ncbi.nlm...log$=pmtitlesearch4
During meiosis, cohesin is required for the establishment and maintenance of sister-chromatid cohesion, for the formation of the synaptonemal complex, and for recombination between homologous chromosomes. We show that REC8 has an essential role in mammalian meiosis, in that Rec8 null mice of both sexes have germ cell failure and are sterile. [beanangel, Sep 19 2009]
[link]
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I clicked on the title fully expecting to see a beanangel idea. |
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What worries me about this is that cancer cells have unusual chromosome numbers, though i think they're generally polyploid. I can't help thinking this might be a way of coming up with new kinds of hydatid mole or sexually transmitted tumour. |
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I edited out the P word
[MB]wrote an item similar to |
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WcW - it is 'cohesin' - the name of a protein. |
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Beany Baby - this is probably your most stupid idea for some time, and that is indeed a not insignificant accomplishment. |
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For one thing, if you start buggering about with one of the key proteins of chromosomal segregation, you will probably have an abortifacient which is 100% efficient, since it will kill the mother. |
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For another, even if you can get antibodies into the relevant cells (and how do you |
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to do that? most cells don't take up antibodies; oocytes almost certainly don't), they'll be proteolysed faster than you can say "happy sugar causes handyphones". If you want to create a virus which infects the cell and then creates an intracellular antibody, I think that's fairly far out. |
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You might as well pick any of a thousand proteins that cells need in order to survive, and |
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to do that? most cells don't take up antibodies; oocytes almost certainly don't), they'll be proteolysed faster than you can say "happy sugar causes handyphones". If you want to create a virus which infects the cell and then creates an intracellular antibody, I think that's fairly far out. |
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You might as well pick any of a thousand proteins that cells need in order to survive, and (go about) knocking them out as a means of abortion. In fact, sulphuric acid has more merits than this idea, as an abortifacient. |
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This is a moronic idea and, whilst I am not one to stoop to ad hominem attacks, I think you're a complete and utter moron with verbal diarrhea. Nothing personal.
— MaxwellBuchanan, Sep 19 2009 |
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"I am in your debt for the editing, Beany, and I am happy to give you credit for the errors introduced thereby. |
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(deleted word) as a word?
— MaxwellBuchanan, Sep 19 2009 " |
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And the answer is? I'm curious as to whether it's an
affectation and, if so, what you believe the point to be. |
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[beanangel] please don't edit the texts. I would have
thought you would have been strong enough to wear
any say given. My reading is not that strong and this
doesn't help. |
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//whilst I am not one to stoop to ad hominem attacks, I think you're a complete and utter moron// |
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sp. "source of harmless and sometimes stimulating entertainment, whom some of us would miss if he/she/it stopped posting, or returned to the mothership in a fit of pique". |
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And do something about that stoop. |
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There are a lot of people on here who are a bit odd. |
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//There are a lot of people on here who are a bit odd//
Yes, but most of us don't advertise it quite so openly... |
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I think the word is exhibit, not advertise. Advertisement suggests it's done deliberately. |
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Wow, I don't understand any of this but I am intrigued by something that is sooo bad that it gets [MB] angry. I especially liked: |
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//you will probably have an abortifacient which is 100% efficient, since it will kill the mother// |
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and the idea that there were other things he said that were so bad they had to be edited and edited in weird ways. |
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All I can say is [beanangel], you are obviously very intelligent, but you seem obsessed with finding larger and larger atomic bombs to kill mosquitoes as many of your solutions seem worse than the problems they attempt to solve. |
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I would love to read (thru a video link, no way I'd be in same room) the warning label if any of these products which went to market. |
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"And please contact a physician if you experience any of the following symptoms: sleeplessness, headaches, explosive diarrhea, vaginal tumors, blindness, rapid aging, vaginal closing, penis growth, genetic mutations or a slow painful death." |
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PS Anyone know a medical term for someones vagina just sealing up/healing over? Like Barbie syndrome or something? |
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//sooo bad that it gets [MB] angry// I'm tolerant of most
things. In fact, there's only two things I hate:
generalization, and all of Beany's ideas. |
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Perhaps you should simply avoid reading, or commenting on beany's ideas. |
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They often strike me as some odd cross-breed between an imperfectly translated haiku and a medical journal, and not very much like a typical halfbakery idea, but that's no reason for me to declare beany mentally incompetent. |
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Considering your predisposition to spot disaster in even the most mundane technological achievent, I'm surprised the both of you have existed here together at all. |
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While I see certain drawbacks to this idea, I've noticed that MB is wont to declare every HB idea a disaster, and frankly, if the two of you can't get along, I'd vote MB off the island, because I'm sick of hearing "You'll make the house collapse by putting in one of those!" every time I have a new door idea. |
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I have to say that i also tend to think a lot of HB ideas would be disastrous in real life, so it's not just [MB]. |
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Half-baked:
adj.
Only partly baked.
Informal. Insufficiently thought out; ill-conceived: a half-baked scheme.
Informal. Exhibiting a lack of good judgment or common sense: a half-baked visionary. |
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[ye] I think the point you're failing to take into consideration
is that I'm a miserable old curmudgeon. When you view my
comments from that baseline, you'll see that they are
generally quite positive. Besides, the house might very well
collapse. |
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//I'd vote MB off the island// Thank God this isn't reality TV... nor reality. The island is big enough. And none of us will win the grand prize. |
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What is the link for? the article is not about cohesin, but about a genetics study related to one component of it. |
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As to the idea: I am not sure whether [beanangel] understood the function of cohesin, yet the question may be immaterial.
The level of solutionativeness in the idea is rather low, and is not lowered by abstracting the idea to 'targeting vital systems may prove fatal'. |
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