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longevity immunization
Some studies show eunuchs live 19 years longer, it is possible that immunizing against testosterone could cause greater longevity | |
I read the eunuchs live about 19 years longer. At the right
age immunizing against testosterone could have minimal
effects on general health and lengthen lifespan.
Regarding sex drive, there is a drug called Foxy that
increases
it in both men and women so it is possible some of the side
effects
could be abated.
Also, there are a bunch of chemical variants on testosterone at the circulatory system, it is possible that some of these are non-libido effecting, and non-physique effecting, but if removed from circulation (immunization) still have a longevity effect.
Slightly supporting that is that some nonfeminizing estradiol, 17-alpha-estradiol, is published as increasing longevity, but I do not know in what laboratory animal.
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"Well Mr. Fundle, the good news is that you'll live to be 105.
The bad news is that you're rejecting your own testicles." |
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It's funny, but in interviews, centennarian women often claim that they lived so long because they rejected other people's testicles. |
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19 years seems extreme. Women are a reasonable testicle
free model system, and they live a bit longer. I think the
biggest difference, which may be testicle related, is that
testosterone makes you do things that get you killed
YOUNG, that's how you end up with a big swing in the
average. |
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There is a chance that metabolites of testosterone are
part of the longevity effect; immunizing against those
could have some of the activity of immunizing against
testosterone. |
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Wikipedia says "as much as 90% of testosterone is
converted into 5α-DHT [dihydrotestosterone] in so-called
androgenic tissues with high 5α-reductase expression,
[146] and due to the several-fold greater potency of 5α-
DHT as an AR agonist relative to testosterone" |
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So it could be that immunizing against
dihydrotestosterone could cause greater longevity
without affecting tissues that produce it as much. |
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//that testosterone makes you do things that get you killed
YOUNG// |
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There's also the fact that, if someone slices your balls off,
you're probably going to be a lot more wary. |
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//There's also the fact that, if someone slices your balls off, you're probably going to be a lot more wary//
True, although illogical in a "shutting the stable door after the horse has bolted" kind of way |
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//as much as 90% of testosterone is converted into
5α-DHT [dihydrotestosterone]// "As much as" is the
key there, a bit like "Some studies" I can show you "Some
studies" that prove all sorts. Quite a lot of it can become
a substrate for aromatase, which makes it into estrogen,
so sort of automatic negative regulation of the androgenic
effects while promoting an overall growth factor kind of
environment. |
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If you wanted to tank your testosterone there are easier
ways than developing a vaccine. Stress your liver, it'll put
out sex-hormone binding globulin. That'll turn down male
and female systems. You could do this with booze...
(Some studies show alcohol lowers teen pregnancy risk...
maybe... anyone?). Statins would be a good way, stress
the liver and deplete the cholesterol that testosterone is
made from. Shame about statins messing up ubiquinone
synthesis. Quite important that. |
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If anyone would like to try this with pills cyproterone
acetate is prescribed for chemical castration as well. |
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If you skip the "acetate" and just get cyproterone it is all
kind of backward. I'm learning something here, often I
ignore the bits on the end of drug names, usually, they're
solubility aids or just the counter-ion. Here, it makes a
difference. Cyproterone is a testosterone receptor
antagonist... which, life being life, causes a response:
massive testicles, more sperm and testosterone. Heh. |
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[bs0u0155] Putting some other thing on the cyproterone other than an acetate is a nifty thought. Perhaps there is testis-mostly/only version of cyproterone like diacetyl cyproterone that passes the testis-circulatory system barrier (I read about it, it is kind of like the blood brain barrier but for gonads, I do not know if ovaries have them as well) but mostly stays out of the rest of the body. |
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Or, aromatase is an enzyme, that to my perception is mostly in the testis, you could make some cyproterone with moeity molecule that only divides to release cyproterone where there is aromatase. |
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Testosterone is known for making men really stupid. Stupid
people die early. I think that explains the difference in
longevity of men with testosterone and those without, it just
a matter of stupidity. |
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Nature is a strange beast, that eunuch is eventually going to break their wall and sire a genetic anomaly that human race wished had existed long ago. Around the corner is the infinite. |
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Then again, fiddling designs may play a part. Carry on. |
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From the title I'm expecting something like suicide booths,
now I'll read it & see how close I came. |
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Nope, not about immunizing people against longevity it
seems, rather than opposite in fact. |
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Errr...according to the news in the DR Congo,
fewer people will die from Ebola, because they
will die of measles (there
is large outbreak of measles there). All we need
now
is for the viruses to merge in a undiscovered
tribe of flying monkeys. |
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Measles, really, are you sure? |
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My mother used to drag me around to disease parties when
I was little (pre-school, under five, the idea was to
immunize you against common childhood ailments b4 you
started school), measles & mumps were definitely among
them & I can't believe she'd have exposed me to something
with a high risk of mortality attached. |
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1900 mortality rates were around 13.3 per 100,000 in the
population, so damn low, & at a time when science, living
conditions & wotnot weren't exactly at peak performance.. |
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So, did you mention the wrong disease there? |
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Not sure what they were really called but if anyone had a kid
with something contagious they used to have a party &
everyone would bring their toddlers to spend time with the
afflicted & 'hopefully' catch it too. |
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Ebola is poised to become quite a serious virus. Incidence
has been increasing year on year, but not exponentially.
However, the higher the incidence, the higher the
probability of its learning some new tricks or swapping a
few genes with other more common bugs. |
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Ebola at present is a bit of a limp biscuit, virally speaking,
since it's not very transmissible and kills its human hosts
quite fast
- that's a naive strategy from a virus that has only recently
taken an interest in humans. It will find its feet before long
and adapt to its new host. |
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It would not be surprising if Ebola rates continue to trend
slowly upwards for a few years more, then surge by a few
orders of magnitude. There's a pretty good chance that
vaccines will stay ahead of it, unless it also picks up some
neat immune-evading strategies along the way. But "staying
ahead" only applies to the subset of the population who
have had the good sense to be born in wealthy countries. |
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[Skewed] How many brothers and sisters did you have? |
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I see where you're going with this :) they're all still with us. |
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