I was thinking about premenstrual syndrome (PMS) and I
thought, It is time to cure this.
I looked up a variety of things online and there is a
quantitative metaanalysis mildly supportive of hormone
therapy in PMS.
Viewing natural hormone levels as a continually time-
varying curve, perhaps
it would be possible to reduce PMS
by heightening, or flattening part of the hormone curves
throughout the month, rather than just a big change a few
days before menstruation.
That suggests a new kind of pillI. Where each day's pill
contains slightly different amounts of escalating or
deescalating hormones or anti-hormones. I think gradually
modifying the amount of the additional hormones, or even
hormone-blockers like metformin from 0 to 100 units
throughout the month could have beneficial effect
compared with acute hormone treatment.
I know there are build-up dose pill regimens but I am not
aware of any dosing strategy with the pills or patches that
continually vary medicine content in sort of curve-
modifying way. These might be beneficial at applications
outside of women's health as well.
Incidentally, looking this up I found a study where 50,000
IU of oral vitamin D a week is described: "The prevalence
of PMS after the intervention fell from 14.9% to 4.8% " The
number of adolescents in the study was 897. [link]
So if you know anybody with PMS they have a 2 out of 3
chance of feeling better with 50,000 iu vitamin D.