h a l f b a k e r yOn the one hand, true. On the other hand, bollocks.
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Cyclic Pharmaceutical molecules, there are a bunch of them! Just make any pharmaceutical molecule have one of the <=> cycles of its cyclic structure be the top of a metallocene molecule (like the sandwich (ti fighter) molecule ferrocene). This creates different pharmaceutical effects as well as different
locationality of the molecule.
Perhaps of value to the pharmaceutical companies is that possibly many preexisting drugs can be reCened this way to be a new profit making drug with improved effects. Thus there is a possible multibillion dollar financial value similar to how chiral drug variants were deemed different enough to have different patents.
Also there are pharmaceutical benefits. It is certainly possible that a multiorganism resistant antibiotic could be reCened to create a new molecule that is absent resistance. With the upper cyclic are part of a known drug, The base of the metallocene molecule could have a bunch of OH groups or hydrogens Which could rotate, possibly effecting a sometimes hydrophilic sometimes lipophilic effect on the entirety of the molecule which would cause it pass membranes more effectively. Also the wide variety of natural yet programmable rotational conformations of the base also cause a wide variety of purposeable receptor affinities. Bremelanotide is a peptide that causes sexiness at one MCR receptor, different effects at a different receptor It is possible that reCening one of the cyclic amino acids at the peptide could cause greater receptivity of this as well as other peptide drugs to create much greater purposed as well as specific activity.
People could also do predictable yet beneficial things like put a salicylate cycle above a statin cycle as a metallocene to create the aspirin Lipitor simultaneous molecule to prevent cardiovascular disease.
Makes billions! Solves antibiotic resistance! Creates greater receptor specificity! Has exclamatory cool moniker!
a metallocene molecule Two cycles with a <=> metal <=>
http://en.wikipedia.../File:Ferrocene.svg
[beanangel, Apr 02 2013]
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I knew this had to be [beany]! Welcome back! I
missed you, several times! (Trebuchets are hard to
aim.) |
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Who needs medical research? Any pharmaceutical
molecule can be a metallocene molecule. |
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This seems to be one in a series, with the common
theme of "do X to all pharmaceuticals". |
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"Do X to all pharmaceuticals" isn't bad, in that it's
more or less how new compounds are generated
for trials. Of course it's already widely covered by
the Pharma industry, and there really aren't any
new ideas there. |
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The step from "Do X" to "this will improve the
compound" is the one that seems to miss about 3-
10 years of clinical trials and actual logic. |
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I also can't figure out how having two attached
compounds is both supposed to improve the
uptake, and act as a simple mixture, since both
are covered in the "idea". |
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If someone becomes allergic to that molecule they
could always allure to a metallurgical metaphor. |
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metallocene synthesis is usually not compatible with water,
and even if you could make these kind of metallocene
derivatives, I'm pretty sure they would breakdown instantly
in any kind of biological environment. [But maybe that's the
brilliance of this idea.. as a way to deliver a drug as a
precursor that decomposes into the active ingredient?] |
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Has anyone noticed that the vast majority of
pharmaceuticals are white? Shirley the time has
come to start making some of these molecules in
other colours. Turqoisify every pharmaceutical! |
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//Has anyone noticed that the vast majority of
pharmaceuticals are white?// |
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There's a very good reason for that. White is the color that
absorbs into the body most quickly, so many drugs are
white so as to provide the fastest onset of effects. White
pills generally dissolve completely within the stomach.
Some drugs, generally extended release medications, are
produced in various other colors, so as to control
absorption rate; these drugs might not dissolve completely
until well into the small intestine, or even the colon. |
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There used to be these washing up liqid bottles called Sqezy. The absence of a U after the Q always made me qeasy. Now i've got that feeling once again. |
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//other colors... might not dissolve completely until
well into the small intestine, or even the colon.// |
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But how can they see in there? |
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