h a l f b a k e r yNaturally, seismology provides the answer.
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Longevity Drug: ethynyl fluororapamycin
Halogenating (placing a fluorine atom at) can cause drugs to have 1000 times potency at the receptor, an ethynylization causes hundreds of times greater activity at the receptor. Combined an 8000-9000 times stronger potency per mg/dose could be possible, applied to rapamycin a drug that causes 60% greater longevity increase could create a one injection drug at humans that causes 60% greater longevity with one injection. | |
Rapamycin is published as causing 60% greater longevity at mice.
Fluorinating drugs like corticosteroids causes them to be 1000 times more active at the receptor, and makes them less likely to be metabolized as well.
Ethynlyzing estrogen causes it to be 700 times more active as an estrogen at less
than 1 microgram (hundreds of nanograms) estrogenic activity at a pill as as compared with 600 micrograms at a conjugated estrogen pill.
Combined, ethynylized fluororapamycin could be 8000-9000 times as active at the receptor. Administered as one time dose of 1 gram as a depot injection or a depot preparation like nexplanon norplant rods people getting the longevity drug treatment could live 60% longer. That is a 246 year on injection supply.
Research to do proof of concept on this could be as little as $15,000 to research 15 different molecular variants of ethynyl flurorapamycin.
Tell everyone you know, and be mention it to rich people who might want to do bespoke research to make them and their loved ones live 60% longer with one injection for a slight adjustment of which car to get.
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I don't think large activity spikes in one receptor is a smart move if it unbalances all the cyclic and buffering mechanisms. 8000-9000 in all participating enzymes, I don't think so. There is going to be blow back. |
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<Obligtory Ethyl Methane Sulphonate reference/> |
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Actually, the patient was dead before he left the table ... |
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"Anti-agathics are here again" |
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"The skies above are clear again" |
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"No smoke from crematori-em" |
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Sung to the tune of Happy Days Are Here Again? |
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[8th] your talents in this respect are called for.;D |
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[Sirolimus, also known as RAPAMYCIN, is a macrolide
compound that is used to coat coronary stents, PREVENT
ORGAN TRANSPLANT REJECTION and treat a rare lung
disease called
lymphangioleiomyomatosis. It has immunosuppressant
functions in humans and is especially useful in preventing
the
rejection of kidney transplants. |
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So an immunosuppressant, so, take it & die much younger
than otherwise from the common cold, or live a restricted
life to avoid contact with any germs that's no fun at all for
longer? |
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It's not sounding like a fun option either way to me? |
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//Ethyl Methane Sulphonate// |
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//So an immunosuppressant, so, take it & die much
younger than otherwise from the common cold, or live a
restricted life to avoid contact with any germs that's no
fun at all for longer?// |
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If you avoid dying of infection, then great. But a lifetime
of immunosuppression will probably mean cancer will get
you sooner rather than later. Rapamycin is a pretty dirty
drug, it has several targets that vary in their binding
affinity and even type i.e. competitive/non-competitive.
There's already a fair few professionals working on
derivatives, some of which I use for a fancy drug-induced
dimerization technique in superresolution imaging. But,
rapamycin isn't going to extend human life. |
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... unless it's a specific for a pathogen you've contracted ... |
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Mostly what [bs] said. I think there's reasonable evidence for
*some* life extension in mice - I don't believe 60%, though.
And what [bs] said about cancer. |
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But furtheralsomore, where did you get this bee in your
bonnet about halogenating the hell out of everything? I don't
buy the idea that it's a blanket mechanism for enhancing the
potency of all drugs - I imagine it might slow down the
metabolism of many, and influence (up or down) receptor
binding, but beyond that it's guesswork. |
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// halogenating the hell out of everything // |
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Well, you could try Astatine ... |
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//you could try Astaine// I always thought Ginger Rogers was
the better dancer of the two. |
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And Gene Kelly was a better dancer. |
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Halo has too much cultural influence especially in people with faster frame rates. |
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I've long thought that a good way to extend longevity
would be to deoxygenate the blood completely and
seal the body off from encountering any more of that
dangerous, corrosive gas. |
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We've been experimenting on that for years, using the feline model. No actual success so far, but that doesn't necessarily mean that there is anything intrinsically wrong with the concept, and we refuse to be discouraged by a relatively small number of unpromising initial outcomes. |
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// people with faster frame rates // |
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... but only an 8-bit CPU with limited adressing modes, and a very restricted amount of RAM. |
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