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When a mosquito, horsefly or other biting insect bites, it first injects a quantity of saliva, which contains anticoagulants and other substances to increase the chances of it getting away with a good meal.
Suppose there is a disease for which the vaccine consists of a protein, rather than an attenuated
or killed whole organism. It should be relatively feasible to arrange for a mosquito or other biting insect to contain such a protein in its saliva. If this is the case, it should be relatively trivial to remove any undesired proteins such as the aformentioned anticoagulants, and add another protein acting as an adjuvant if necessary, etc.
So then it would be possible to vaccinate against this disease using these medically produced mosquitos.
Why would this be an advantage over the traditional way using needles? It may well be safer, with less risk of contamination and causing less skin damage. Production may be cheaper, and easier to scale up. And it may be medically advantagous, if the protein needs to be post-translationally modified in a eukaryote. And after use the mosquitos can be easily euthanased, instead of costly disposal in a sharps bin.
Prior art
Mosquito-spread_20immunization
Mosquito-spread immunization (a rather different take) [Loris, Jun 25 2008]
Testing... testing...
https://www.nih.gov...uito-vaccine-tested
Hmm... [RayfordSteele, May 22 2021]
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This, if I may say so (may I?) is a bloody
good idea. |
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It could also be done on a mass scale,
simply by breeding large enough numbers
of the insects and releasing them. There
would be issues over this, but also
advantages - perhaps for immunizing
animals that harbour zoonoses. |
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Oh, and "euthanased" - Sp.: "squished". |
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Or for those with ethical scruples, use wasps, on the principle that it's good for you, but it still hurts .... |
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We humans never seem to get anything right the first time. (+) for innovative thinking, but I've got a bad feeling about this one. |
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I don't think you could remove the anticoagulants as it would make them fail to be able to eat, so you wouldn't have to squish them as they'd starve. |
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Could they be used to spread iodine? |
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Previous ideas have mentioned that you only need a tiny bit, maybe the skeeter spit would have enough. |
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I'll surely feel better when the ability to
spread hordes of customizable mosquitos
will be in the hands of humankind. |
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Brilliant idea. A lot of pathogenic bacteria, which are problems in developing countries, have pili that are recognizable by antibodies. You could modify the mosquito to secrete these into its saliva. |
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However, releasing large amounts of mosquitoes can spread other diseases for which there may be no cure. Plus there is no evolutionary pressure to retain the protein, so you would have to keep breeding them and releasing them. |
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I guess it's a trade off. |
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Slight ethical objection that you are doing this largely without the consent of the patient. But this never stopped them putting iodine in water so why not? Bun |
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Finally, a way to make doctor’s visits fun! The patients would sit naked under a mosquito net while a horde of biting insects swarms around him. “Remain calm, we need 97 nice large bites for this one, with lots of ear and eyelid bites this time. Let’s give it half an hour. And no swatting.” |
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ha ha.. interesting.. but playing around with nature is dangerous.. |
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I'm not suggesting releasing these mosquitos into the wild. If they didn't have anticoagulant in their saliva they probably wouldn't survive without mollycoddling anyway. |
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The aptly named Amos has it about right, although the biters would probably be contained in a small jar with a thin membrane lid, to be held against a suitable bodily area. |
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//ha ha.. interesting.. but playing around with nature is dangerous..// |
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Nature needs playing with at all times, just for human civilisation to exist. |
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Interviewer: Now, let's see ... your former job was..... mosquito molycoddler ? |
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Interviewer: Ah. And what did that involve, exactly ? |
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Applicant: Well, basically, waiting hand and foot on a bunch of tiny, irritating bloodsucking insects. |
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Interviewer: And what made you consider a career change to being a legal secretary ? |
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// just for human civilisation to exist. // |
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You lot have got yourself a civilisation now ? Where ? Show ! |
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...so the third master steps forward, opens a matchbox and releases the mosquito.
Unsheathing his katana he traces a figure eight in the air and resheathes the weapon. |
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The man looking for a bodyguard says, "What would I want him for? The first guy you showed me cut the mosquito in half and the next guy cut it in quarters, but this guy didn't even kill it!" |
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The old grandmaster says, "Ah but third mosquito never make babies again." |
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Two years before the Japanese, and eight years before me!
Idea bumped for kudos. |
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Only just seen this. I can see how this works, but what
happens if the same type of mosquito bites again after the
immune system is wise to the protein? Do you get a HUGE
golf ball sized lump as the immune system wades in to
destroy everything and anything near the mosquito
introduced protein? What happens if you're bitten 20 times? |
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