ATP (or possibly metformin) liposomes as beauty technology

first an ATP observation. I think I read that 90 lbs (!) of ATP is actually continually regenerated each 24 hours at a human (ATP->ADP->ATP again) so a few milligrams of ATP might not do much... unless it only enriches about a millimeter thickness of tissue like at the dermis.

metformin is published as causing lab mammals as living about 1/3 longer (some will say 1/5th) so making a dermal creme that causes people to age 1/3 slower when they use it is at least testable. Another possibility is rapamycin. rapamycin is bad for people systemically, yet might be harmless topically. Both of these function from something similar to sugar response calorie restriction like effects, they are just topical rather than systemic versions.

so the ATP (or metformin or rapamycin) soaks in, scientists measure if it has any effect, and actual protein synthesis goes up at the dermis. preferably, people look nicer.