Some pharmaceutical drugs produce a rebound effect: A
blood pressure medication might cause less of the
naturally
occurring blood pressure reducing biochemicals to be
produced.
What if you gave people metabolites of drugs to heighten
that bodywide opposite response even while you were
medicating
a problem locally?
One possibility is using metabolites of drugs as source
chemicals.
Dosing the person with the metabolites at nonessential
areas would cause 90% of the body's response to the
molecule would be to make a "make more useful stuff"
rebound effect instead of "make less useful stuff"
rebound
response.
You could give an opposite effect drug to an uninvolved
large body compartment like the GI-tract: One example
is
sending dopamine reducers to only GI tract neurons.
That
then causes the body to upregulate dopamine production
globally, causing the brain to produce more dopamine as
it
“rebounds” from the GI-tract-only dopamine reducer.
This
causes better mood and sense of reward from the
increased brain dopamine. A happy pill.
One reason to use metabolites as drugs is that they might
occupy activity-producing receptors with much less
produced activity, sort of blocking the receptor.
Other new drugs that might work this way:
At dermatitis or inflammation, could you heighten
something like a dermatitis chemical response (without
any
actual tissue harm) at something like the large, rapidly
renewing GI-tract’s volume? That causes the entire body
to produce a larger amount of inflammation and/or
dermatitis reducing chemicals. That would work on
broad
or diverse skin areas. This could be a pill to reduce or
cure
atopic dermatitis.
Some dopamine drugs are psychiatric drugs. An anti-
schizophrenic drug: a GI-tract dopamine rebound
producing
molecule could upregulate or downregulate the body's
chemicals that affect D(1,2,3,4) receptors or the
receptor
affinity modifying chemicals, with all the side effects at
only the GI tract and not at the brain. That minimizes
sedation and fuzzy-headedness from psychiatric drugs.
This could also work with serotonin and antidepressants.
Cotinine is a metabolite of nicotine. It has a calming
effect. I do not know if this if from receptor blockade or
not.
A nootropic (intelligence increasing) drug that works this
way might be a big dose of active-only-at the GI-tract
cotinine that causes global bodywide up-responsiveness
of
the smartness producing nicotinic acetylcholine
receptors,
notably at the brain, increasing functional intelligence.