h a l f b a k e r yNot so much a thought experiment as a single neuron misfire.
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immunoreset
causing immune system to lose its receptors for a certain illness | |
White blood cells have receptors that discover illnesses
encountered, but as people age, there are many false alarms
causing autoimmune diseases.
Our research discovered in its second half how to cause the body
to eventually lose its immunity to specific biochemical markings.
Once that
is done diabetes type I and many other illnesses can be
treated...
vaguely related
https://www.ncbi.nl...gov/pubmed/23902557
[pashute, Apr 30 2018]
strongly related....
https://www.monash....immunology-ideology
hmm.. interesting read [pashute, Apr 30 2018]
perhaps a start?
https://onlinelibra...f/10.1002/art.11072
[pashute, Apr 30 2018]
Flatliners
https://www.imdb.co...82/?ref_=fn_al_tt_2
Restart from cold. [8th of 7, May 02 2018]
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Annotation:
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Umm, sure, but how exactly do you propose to "reset" the
immune system? |
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chlorine. Lots of chlorine. Getting it to start again could be
tricky. |
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Isn't there a button on the back somewhere? |
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So, I read the middle link, and the new fact in it is //the T-cell
receptors associated with type 1 diabetes can bind to the MHC in
the opposite orientation [i.e. opposite to the way they usually
bind].// |
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I'm not doubting that it's important in some way, but how do you
get from there to resetting the immune system? |
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// Isn't there a button on the back somewhere? // |
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Depends which version you have. Maybe there's an OBD II port somewhere ? |
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We suggest powering everything off, pulling all the breakers, waiting five minutes, then powering the systems up again one at a time checking each one for faults as you go. <link> |
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[marked-for-deletion] magic |
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The problem with resetting the immune system is that you'd
have to somehow repeat what happens before birth. |
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The immune system starts out with gazillions of random
targets. Before birth, any immune cells that recognise
anything get killed. Hence, any immune cells targetting
normal body components should get killed off. This is your
main protection against autoimmunity. So, when you're
born, your immune system consists of cells that recognise a
random selection of "non-you" things. |
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When you get an infection, some of the cells will happen to
recognise the infectious agent, more or less. Those cells
then proliferate, but they also evolve in an attempt to
make the recognition stronger. |
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Unfortunately, if an infectious agent resembles a normal
body component, then the "evolution" stage can lead to
immune cells that recognise that body component as well as
the infectious agent. Other factors can also trigger immune
cells to mistakenly evolve towards targetting normal body
components. Either way, the result is an autoimmune
disease. |
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Once autoimmunity gets started, it's very difficult to stop.
The cells responsible for it have no way to know they're
targetting your own body - they just think they're fighting
an infection, and so they proliferate and get more and more
aggressive. The whole "friend/foe" business can only
happen before birth, when there are no "foes". After that,
it's very difficult. |
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//Once that is done diabetes type I and many other illnesses
can
be treated...// |
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That wouldn't be all you could do with it, you could use any
old animal organ you wanted for transplants. Lost an arm?
graft on a Gorillas. |
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This made me think of an immune system with brains, well a matrix with some tiers of filtering.
Bad, bad but good; good, bad, good but also good. |
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This would need an antibody to a bound antibody already bound to an antibody bound complex and a very discerning white cell or groups of white cells. Far from the normal, antibody bound is bad, engulf. |
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No metaphysical logic though, just the intrinsic fabric of the universe's pieces recursing up shape wise to say what's good and what's bad at a higher scale. |
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Clearly what’s needed is a government immunity
system interface to decide what a good cell is and
what a bad one is. Maybe in IBM Doors. |
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there's a difference between impossible and very difficult.
And that's the diff between magic or wishful thinking and the
beginning of a discussion on an idea, that isn't being discussed
because people think it's impossible. |
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The second link is claiming that there may be a way to
develop T cells that work regularly BUT can be controlled, via
some extra drug, which can turn them on or off. The link
claims also that established knowledge about the T cells
formerly considered to be complete is now being re-visited. |
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Are you sure that's what it says? The way it reads to me,
receptors in the different orientations behave in the same way.
So, if you wanted to use the orientation somehow as a control
mechanism, it would be like a switch that toggled between ON
and ON, with no OFF state. How would that help? |
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