h a l f b a k e r yTrying to contain nuts.
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Keppra aka levetiracetam is a seizure drug. I am not sure how these things are discovered but the target is some brain receptor with uncertain function; see link.
Keppra has the unusual side effect of predisposing to rage; see link. This is not combativeness with confusion like someone drunk, but
just short temperedness. A weird side effect.
Maybe the protein targeted by this drug (something called SV2A) is important for rage. Maybe the people with rage problems have some deficit in quantity or function of this, or in people who have rage problems for other reason (eg dementia) increased SV2A function might help with that. I propose that a drug could be designed to bind SV2A to do the reverse of keppra. One would expect such a drug in excess might also lower seizure threshhold which would not be good.
If this does not bring beanangel out of the woodwork nothing will.
(?) Levetiracetam
http://en.wikipedia.../wiki/Levetiracetam [bungston, Mar 25 2011]
Keppra side effects
http://www.ncbi.nlm...gov/pubmed/14741183 Hostility is hostile! [bungston, Mar 25 2011]
Stronger cite
http://www.ncbi.nlm...gov/pubmed/14527496 [mouseposture, Mar 25 2011]
Irrational anti-rage drugs
http://www.ncbi.nlm...gov/pubmed/19744405 [mouseposture, Mar 25 2011]
Wikipedia: The Terminal Man
http://en.wikipedia...ki/The_Terminal_Man [rcarty, Mar 26 2011]
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Actually, of the common AEDs, [seizure drugs] ONLY
levetiracetam has been shown to be INeffective in the
treatment of impulsive aggression. (That's a quote from
<link2>, emphasis added.) |
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However, these aren't *rational* anti rage drugs -- more
like
"this is already marketed & safety-tested for epilepsy, let's
try it for a psychiatric indication because AEDs usually turn
out to be useful for those" drugs. |
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So this is a really good idea, *and* it wouldn't necessarily
lower seizure threshold. |
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Levetiracetam. The Berserkers might have taken something similar. |
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