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Peptide DDT
Wikipedia says banning DDT may have killed 20 million people; PeptideDDT attaches a highly immunoreactive protein to one of the benzenes on DDT; this new kind of DDT is hyperattractive to bird n mammal macrophages thus minimizing environmental risk Epitalon with a fully chlorinated phenylalanine dimer might be the DDT workalike that if removed from the environment would make birds fish n mammals sicker thus there is a regulatory advantage to permitting Epitalon chloro diphenylalanine | |
Bill Gates Foundation is putting much effort towards a malaria cure
Wikipedia notes the human application complexity of using things like DDT to reduce disease: Robert Gwadz of the National Institutes of Health said in 2007 that "The ban on DDT may have killed 20 million children."[101] These arguments
have been called "outrageous" by former WHO scientist Socrates Litsios and May Berenbaum, a professor of entomology at the University of Illinois at Urbana-Champaign, says that "to blame environmentalists who oppose DDT for more deaths than Hitler is worse than irresponsible."[79]
My appllication is just to attach a highly immunoreactive peptide to one of DDTs benzene groups such that the moment a mammalian or avian or amphibian or fish macrophage detects the peptide the peptideDDT gets immunoprocessed I'd like to say metabolized
Bugs lack macrophages thus the bugs still die from DDT
depending on the reactivity of the peptide plus the liver enzyme macrophage processing steers the peptideDDT towards there might be a thousandth the effect on animals plus preferential creation of a preferred physiologically benign organic metabolite
DDT
http://en.wikipedia.org/wiki/Ddt
gorgeous molecule featuring 1,1,1-trichloro-alwayslookonthebrighsideoflife-2,2-bis(4-chlorophenyl)ethane [beanangel, May 02 2009]
a carbohydrate that alerts the immune system
http://en.wikipedia...ding_lectin_pathway
[beanangel, May 03 2009]
epitalon promotes mammal longevity
http://www.citeulik...nush/article/233918
[beanangel, May 05 2009]
[link]
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I don´t think this would work at all. It sounds like it would trigger anaphylaxis in vertebrates, kill them, then the DDT would be released into the environment anyway. I couldn´t swear to that but i find it hard to imagine that it wouldn´t happen. |
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This is only dumb for a few reasons: |
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1) It's very unlikely that DDT will work as an insecticide if
it's glued to the side of huge protein molecule. |
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2) If higher animals ingest your protein-DDT (or did you
mean peptide-DDT?), and if they do degrade the protein
component, you'll be left with a DDT molecule with a few
amino acids glued to it. I wouldn't be at all surprised if it
were as toxic as DDT, and probably harder for the body to
eliminate. |
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3) DDT is good because it's cheap and stable. DDT coupled
to a protein will be expensive and unstable (aside from the
fact that it won't work). |
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This is once, twice, three times a lame idea. |
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I was thinking yall would suggest putting a hydrocarbon effect separation molecular spacer between the peptide /\/\/\/\/\ DDT That is how they attach fluorophores to small drug molecules to preserve small molecule function while finding their sites of action with fluorescence |
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[MB] There are numerous peptides engineered to pass the GI tract I've read references about this |
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I am thinking that the particular peptides amino acids might cause the entire molecule to be associated with distinguishable p450 liver enzymes such that the products are metabolized if I may use that word to specific known chemicals |
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//a hydrocarbon effect separation molecular spacer// You
mean a linker. Yes, so what? It's still unlikely that DDT is
going to work like DDT when it's tied to a protein. |
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//There are numerous peptides engineered to pass the GI
tract I've read references about this// There are indeed,
and I'm sure you have. So what? |
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//I am thinking that the particular peptides amino acids
might cause the entire molecule to be associated with
distinguishable p450 liver enzymes such that the products
are metabolized if I may use that word to specific known
chemicals// Gibber gibber gibber. |
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Beany, beany, beany - as I've said before, if you can't filter
the input, at least filter the output. |
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for crissake take a chem class. |
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Despite the prevailing opinions, it's a nice thought. |
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why aren't there more amateur chemical engineers? |
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Ah yes, lots more scavenging of outputs.In fact, a
new ecosystem would do nicely. |
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[WcW], there are probably quite a few, it's just that they work in rather clandestine but profitable areas, often involving imports from Columbia. People just need to be "correctly" motivated. |
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//why aren't there more amateur chemical engineers?//
Natural selection. |
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and the desired metabolic pathway is..... |
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If we can figure out a DDT replacement Wikipedia notes that Mosquitoes are estimated to transmit disease to more than 700 million people annually |
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Here is a clownish speculation you may like |
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ethidium bromide is known as a DNA attaching agent; it is also a pesticide |
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from the structure it appears ethidium bromide can be both hyperchlorinated to act like ddt plus you could have a peptide on it that would preferentially attach to naughty dna like the common cold virus dna This would create a pesticide that also reduced the transmission of the common cold |
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this clownish speculation has a useful idea though are there any organochlorine compounds that are generally beneficial to humans If there are then modifying these beneficial compounds to be insecticides creates a multiple benefit |
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I'm under the impression that there are halogenated aspirin derivatives; just possibly there is an insecticide that reduces cardiovascular disease |
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Methoxychlor is basically DDT with OCH3 it had a lot going for it but was phased out 2003 Its possible that a DDT-CHO carbohydrate would be unusually susceptible to vertebrate metabolism while being a strong insecticide Mannose-DDT appears to have a high likelihood of being rapidly immunoscavenged plus having activity kind of like DDT or methoxychlor |
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Any ideas readers have on vertebrate beneficial insecticides here 700 million people annually staying well from a truly beneficial insecticide is a bunch |
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//If we can figure out a DDT replacement Wikipedia notes
that Mosquitoes are estimated to transmit disease to more
than 700 million people annually // Oh, right. Jolly good
idea, we must go and advise the chemists that we have a
new project for them. |
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And this year's award for Utter Bollox goes to....... |
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every single one of bean's ideas has a tinge of WIBNIfty to it. Wouldn't it be nice if science worked really well and was easy and simple and anybody could grasp it simply by reading abstracts. |
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That DDT molecule is nifty. Fearful symmetry. But suppose it did have a peptide thinger and a macrophage grabbed it. Could it hold it? DDT is fat soluble. I suspect the macrophage would be able to bust up the peptide, or the attachment piece, and then the DDT would wander back out through the cell wall en route to some nascent eggshell. |
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[bungston] I appreciate the nifty science thoughts |
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while I ponder what you say what do you think of this idea Attach the 4 amino acid longevity peptide epitalon to a fully chlorinated phenylalanine dimer (two phenylalanines looks like DDT) to create a insecticide that actually makes vertebrates live longer |
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The regulatory advantage of epitalon DDT is that if it were removed from the environment fewer birds fish n mammals would live than if it were present |
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The point of killing the bugs being rescuing 700 million people from mosquito sickness each year |
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technology: make phenylalanine dimers then chlorinate with chlorine plus ferric chloride then attach to eptalon peptide with a condensation reaction |
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//every single one of bean's ideas has a tinge of WIBNIfty to it// What about the iodised ink? That looked OK to me. Post-it notes which change colour as they get more urgent? Also good. |
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2 polychlorinated aromatic rings sounds like polychlorinated biphenyl. I am not sure how a chemical would make vertebrates live longer. |
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//Attach the 4 amino acid longevity peptide epitalon to a
fully chlorinated phenylalanine dimer (two phenylalanines
looks like DDT) to create a insecticide that actually makes
vertebrates live longer// |
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Beany, beany, beany - dumb, dumb, dumb. Different
molecules behave differently. Thalidomide happens to
look like guanine fused to thymine - both vital
components of that Jolly Good molecule, DNA. I have
seen clouds that look a bit like wallabies. I even know a
woman who has a mole that looks like Cyprus (though not
as large). |
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If you're interested in chemistry, molecular biology and
suchlike, then there are lots of quite good books on the
subject. Bless. |
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I think even a seasoned chemist would create a group of related molecules then measure them I think DDT-mannose as well as Epitalon DDT are of value |
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DDT is different than a PCB even though it is literally a polychlorinated dibenzene |
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epitalon is published as being active at microgram quantities, which weirds me out a little |
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anyway I put up an epitalon link |
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Mosquitos are thought to feed so they get protein to lay eggs, its possible there is a chemical that tells mosquitos they have sufficient protein even absent feeding, it might be a satiety peptide |
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as easy as I may be to criticize I urge you people to think a little on a new insecticide that cures malaria |
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If we were really going to creative though we would think of a way to transcend the quality of government. Its quite possible that if the afflicted regions had what I think of as near functional governments methoxychlor could have been used to eradicate malaria |
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I think the Gates foundation likes malaria treatments as sick people are more likely to seek a cure than governments are to be competent |
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//easy as I may be to criticize I urge you people to think a
little// |
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The problem, Beany, is in your signal to noise ratio. |
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You have a habit of saying "Look what I've just read" and
then extrapolating without a licence. Not all of your ideas
are dumb, but you affect this peculiar writing style, which
is recognisable but makes it like trying to read with one
eye tied behind your back. Also, if you are extrapolating
far enough to get from A to Z, you would often to better
to think about starting from X or Y instead, or at least
learning the rudiments of B through Y. |
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The world is full of truly amazing facts. The skill is not in
finding an amazing fact and jumping from there to your
goal. It is in (a) finding amazing facts which are also likely
to be correct and (b) finding a plausible [even by HB
standards] way of getting from there to your goal by
ground instead of by air. |
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In his defense, bean's ideas are always halfbaked as according to the HB charter, in that every single one is a poorly thought out idea for an invention. Each has a germ of science. All seem generally without malice and intended to benefit humanity. Beany is quite durable as regards ad hominem attacks. I admit that I saw red for the briefest instance the last time I found one of my annos deleted and repasted, but then I remembered it was just the Halfbakery, which is for fun. |
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Believe me, I would miss our Beany. But his ideas need more
filling in between the bit that goes "scientists have recently
simulated the distribution of matter in a model universe"
and the bit that goes "could reduce the risk of catching bad
smallpox from handyphones" |
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Simply saying "I think that adding a "peptide" to DDT could make a better pesticide" without recognizing that the smallest synthesized peptide is hundreds of times more massive than a diphenol and that this would be the rough equivalent of attaching a rubber dinghy to an aircraft carrier. |
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Complete lack of functional understanding. |
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Would attaching a DDT molecule change the properties of a peptide? Maybe, depending on which of the thousands of places you put it, but I doubt that this final molecule would be an insecticide. |
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The idea isn't just comical, it is completely ludicrous, and shows a completely superficial understanding of the scientific vocabulary it contains. A "snow job" so to speak. |
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