h a l f b a k e r yA riddle wrapped in a mystery inside a rich, flaky crust
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Menstrual cramps are a big problem for many women. Pain pills help, but not completely, and these often have undesired side effects. Menstrual cramps are caused by contraction of the smooth muscle of the uterus, probably as part of the process of sloughing the endometrium (menstruation).
Nitric
oxide is a small molecule which is used to cause smooth muscle relaxation. (link) The best known use of this is in the form of nitroglycerine tablets, which relax the smooth muscle surrounding vessels in the heart, allowing them to open. Taken systemically, NO-delivering drugs cause side effects like low blood pressure and headache. Interestingly, nitroglycerine sometimes has the good side effect of relieving smooth muscle spasm elsewhere - like the esophagus.
Locally applied nitroglyicerine can also relieve spasm, with fewer local side effects. An example of this is nitroglycerine applied to treat anal fissures (link).
Uterine cramps are just another smooth muscle contraction. I propose that tampons with a small amount of nitroglycerine could deliver nitric oxide locally to the uterus, relieving muscle spasm and the pain of cramps. The tampon is a good vehicle for this: nitroglycerine has a short half life and needs frequent renewal - already the case with tampons.
Nitric oxide review.
http://users.rcn.co...logyPages/N/NO.html
[bungston, Oct 05 2004, last modified Oct 17 2004]
Nitroglycerine for anal fissures
http://content.nejm...November&tyear=2003
Several hits in this page discuss this topic. [bungston, Oct 05 2004, last modified Oct 17 2004]
Vaginal prostaglandins
http://www.ferti.ne...ss/eshre2000_31.asp
[bungston, Oct 05 2004, last modified Oct 17 2004]
cricket box.
http://www.cartoons...y/c/cricket_box.asp
[po, Oct 05 2004, last modified Oct 17 2004]
US patent 7,341,737
http://patft.uspto....41737&RS=PN/7341737
Medicated tampon
Claim 15. The tampon of claim 8, wherein the vasodilator is selected from the group consisting of nitroglycerin... [xaviergisz, Dec 30 2008]
Nitroglycerine for dysmenorrhea
http://www.ncbi.nlm...nel.Pubmed_RVDocSum
#1 side effect was headache. A lower dose locally applied might produce less headache. [bungston, Mar 12 2009]
Clinical trial of transdermal nitro vs NSAID
http://www.ncbi.nlm...nel.Pubmed_RVDocSum
Both worked. Nitro was limited because of headache. [bungston, Mar 12 2009]
[link]
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would there be a TSS risk? |
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Based on the anal fissures abstract, since 25% of the
nitroglycerin group experienced moderate-to-severe
headaches, it seems the botulinum toxin would be the
preferred pharmaceutical to use for such an invention,
wouldn't you agree? -In addition to the evidence it was
more effective. |
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I have to hand it to you bungston, there would be no
concern for abuse by over dose... Do these ideas of yours
ever cause you brain cramps? Just curious ;b |
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Combine this and Viagra into the same pill, "For Explosive Results!" |
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[Ray] You're not supposed to eat them. |
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A Larsson Far Side idea... Cramp!!! BOOOM! |
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[bliss] - I don't think the spasm is necessary for the slough - seems like some women menstruate just fine without them. As regards TSS (toxic shock syndrome)- this would be changed out like any ordinary tampon, which it would be; TSS risk increases when tampons are left for a long time. [Buddha] is spot-on with the similarities between those things, though the Rogaine one is a surprise to me. [Tiger Lily] - I also would prefer botox for the fissue use - but nitro might be better for the cramps just because it would be hard to deliver botox to something as big and deep as the uterus. |
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I am surprised at all the bones. Maybe it is the title. Or people who like cramps. |
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// You're not supposed to eat them // |
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Mmmph...*gulp* You're not? |
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I think this could be dangerous for blondes. One detonator, wire connected to battery pack converts this into one hell of a vibrator |
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//tampons with a small amount of nitroglycerine could deliver nitric oxide locally to the uterus// |
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It would have to be longer than a normal tampon would it not? Tampons are normally worn on the vaginal side of the cervix. And how receptive would an unsloughed uterine wall be? Could the nitro get through to the muscle layer? And are you pronouncing that "sloo" or "sluff"? |
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That reminds me, I'm out of
sodium nitrate. Anyone want to
lend me a kilo? |
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Or "slow" as in the town of Slough in Berkshire |
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thats slough as in plough.. |
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Ah. Yes. Thanks [po]. Too early in the morning.... |
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Good observation, [UB]. Bronchodilators are basically just adrenaline and its cousins. These same drugs are used to reduce uterine contractions during labor. It stands to reason that they might also be effective for non-pregnancy related cramps. |
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This would be even easier to test than the nitro idea. Got cramps - take a few puffs on a bronchodilator. |
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Croissant, if only for the explosive sex that would result. |
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And you thought Richard Reid trying to light his shoelaces was a problem... |
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//nitroglycerine has a short half-life and needs frequent renewal - already the case with tampons// |
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Oh bugger I forgot to remove it after 8 hours...BOOM! |
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This might make your vagina numb, but it would have little effect on the uterus. Provided an average-to-slim figure, it would be just as effective to use a topical painkiller on your abdomen, considering the distances involved. |
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I think the venous drainage from the vagina runs really close to the uterus. Linked is an article describing a study in which vaginal prostaglandins created a higher uterine drug level than intramuscular - from which they conclude that this is an effective way to deliver drugs to the uterus. |
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Well paint me green and call me
Gumby, this might work. + |
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Also convenient for less violent yet practical jokes. |
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Hide one in your mother's box of laundry detergent and
watch the SOAPBOX go BOOM! |
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Hmm, considering it hardly resembles one... however there are plenty of names for genitalia which don't resemble them ('pork sword' for example). |
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Assumed relationship: a box is an object that is designed to hold another object. |
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Couldn't find it in the oxford english disctionary. |
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[bungston] You've got to get a better dictionary |
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Collins Concise Dictionary (the big fat expensive one); |
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box, meaning no. 16: Austral.taboo sl. the female genitals. |
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"you were only meant to blow the bloody doors off" |
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[aka] you don't wanna know |
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Dymanite is composed of nitroglycerine, and cellulose, isn't it? |
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The cotton in tampons is composed of cellulose too. |
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Would that make this idea... DYNAMITE! |
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I caught a nitro headache working with some explosives that were sweating. Worse than a migraine. |
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Dynamite is nitroglycerine absorbed into Fuller's earth
(diatomaceous earth), rather than cellulose. |
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Someone was bagging on this idea in the annos of another idea. But this would work. I linked up a review. |
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Doesn't Viagra have a similar effect of blood vessles? |
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