Internalized Antibody-Caspase Conjugate Therapy

There is currently a monoclonal antibody(MAB)-based therapy on the market called Trastuzumab emtansine. It works by binding to receptors found on specific breast cancer cell types; the HER2 receptor. Then, the receptor and antibody are internalized by the cell, then, a few molecules of some nasty chemotheraputic agent go to work, nicely targeted by the MAB system.

I think we can improve upon this, the drugs that they can attach to the antibody are limited, they pretty much have to use stuff that sticks to proteins. This is not as good, for example as attaching a lovely active caspase to the antibody. Caspases are specific proteases which induce apoptosis, cell suicide. The cool thing about them is that they have no role outside cells, so when circulating around in the blood they'll be totally harmless. When internalized into the cells, they will be more effective than small molecules because the caspase system is adapted to be a self amplifying cascade. There, a sensible workable halfbaked cancer idea.