h a l f b a k e r yWarm and Fussy
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Gillette Vital Edge
cardiovascular protectant: like getting millions of people to take acetylsalicylic acid daily | |
Gillette Vital Edge gives you fresh cool lather that actually uses your body's chemistry to protect your heart
while the foam is all over your face platelet drugs linked to passivation molecules are absorbed
these go though the liver called first pass metabolism to become cardioprotective
Gillette
Vital Edge users like acetylsalicylic acid users have a seventh fewer cardiac events, with perhaps better than that with a more platelet active drug like a nitro-aspirin
humor value: how can anyone resist the phrase powerful nitro-aspirins give you the Gillette Vital Edge
technology:
3,4-dehydro-cilostazol is published as effective against atherosclerosis plus the [link] suggests its maybe 11 times more active per milligram than acetylsalicylic acid; that makes the dose 2 or 3 mg which could go with a ml or two of product
Chemists frequently use halogen atoms to make molecules grippier; diflunisal is a salicylic acid with two fluorine atoms positioned such that its harder for the liver enzymes to digest; diflunisal is only about as good as acetylsalicylic acid at thrombosis things but it lasts 3 or 4 times longer; a different fluorinated or chlorinated acetylsalicylic acid variation might well be a stronger platelet active drug than acetylsalicylic acid to create a wonderful milligram or less dosage
previously I thought coumadin would be the drug at just 200 micrograms up to a milligram; it might be useful as well
Assertive Grandiose Hype:
possibly more effective than a national healthcare system at reducing mortality (US n Europe numbers are just a little different; a seventh reduction of a disease that effects two out of three people might be larger than that difference)(humor value: but just try asking a pile of foam anything)
that triple blade vibrating razor thing was worth billions
this is public domain though
popular culture: I've read humorists wondering what would come after the multiblade vibrating razor as the New Tech to provide product difference at a value that justifies the premium
they could even have a mecha looking dispensa cap that filled with gas such that the container would only deliver a certain amount over an hour period to keep depilatory enthusiasts from absorbing too much drug
effect of acetylsalicylic acid on patients with stable cardiovascular disease
http://www.ncbi.nlm...nel.Pubmed_RVDocSum
I didn't look up the prevention figures on an unscreened population [beanangel, Jan 24 2008]
coumadin prescribed at 1 milligram dosage; racemic form is much stronger so as little as 200 micrograms could be therapeutic
http://66.218.69.11...QGga&icp=1&.intl=us
[beanangel, Jan 24 2008]
aspirin prophylaxis
http://www.ncbi.nlm...bmed_RVAbstractPlus
good stuff [bungston, Jan 24 2008]
Effect of transdermic acetylsalicylic acid on hemostasis in healthy volunteers
http://www.ncbi.nlm...nel.Pubmed_RVDocSum
12 ml is rather a bunch [beanangel, Jan 25 2008]
might work at near a milliliter
http://www.fda.gov/...azol/cilo_label.htm
30 mg dose ---> 3,4-dehydro-cilostazol (4-7 times as active as cilostazol)-->7mg drug --->doubles as it accumulates physilogically --->2 or 3 mg [beanangel, Jan 25 2008]
flurbiprofen
http://www.ncbi.nlm...nel.Pubmed_RVDocSum
tarted up [beanangel, Jan 25 2008]
nitro-aspirins (what a phrase)
http://www.ncbi.nlm...nel.Pubmed_RVDocSum
the nitric oxide from the nitro-aspirins is platelet active; perhaps better than acetylsalicylic acid [beanangel, Jan 25 2008]
Gillette Fusion
http://www.gillettefusion.com/us/
5+1!!!! [GutPunchLullabies, Jan 26 2008]
[link]
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[marked-for-deletion] probably bad science, but there's no way of telling |
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there has been a rewrite; I used lazy language at the idea because the lazy language went with the idea of functional group, chelation or lipid microspheres |
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I think it is an adequate idea; it has a bunch of published chemistry plus a touch of humor |
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I think Ian Tindale rescued it with the idea of all those vaginas |
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//its an adequate idea with a jerky tone//
...and not a single comma or period. |
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There are two ideas here, one which (in my opinion) fits the remit of the Halfbakery, one which does not. |
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One idea is for hoxyboxynucleosomethingorother riboflavicacid diethylamide to be used to 'help' heart conditions. Quite how this works is completely beyond my realm of experience - apparently there are some studies about it, but if there are studies, then someone else has already invented it. Haven't they? |
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The other idea is a new delivery method for drugs. |
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The intractable gumpf about this or that drug is of absolutely no interest to me, is unoriginal (see links) and doesn't fit the remit of the Halfbakery. |
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The actual idea could have been presented far more simply as (for example) 'Aspirin Shaving Foam' and marketed to people suffering from the "Morning After", high blood pressure, or plain old hurting faces. |
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This delivery mechanism is a new idea, has some benefits, and is a poorly thought-out idea if ever I heard one. It's just a shame that it's obscured by all the impenetrable pharmajargon and missing punctuation. |
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How would nicking your face affect drug absorbtion? (sp) The vibrating razor made billions? I thought that was one of the worst ideas EVER, having the experience that any lateral movement causes cuts, I laughed when I heard about the vibrating razor and then never heard about it again. Is it popular in Europe? I thought it went the way of the EpiLady female torture device? |
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The Gillete Fusion *Power*, like all glossy disposable loss-leaders that are churned out for next to nothing in plastics factories, then packed in yet more plastic, and sold with *BIG* s h i n y ADVERTISING campaigns that *H*Y*P*E* everything with COMPUTER graphics and lots of !!S!W!O!O!S!H!I!N!G!! about, are inherently bollocks. |
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I have one on the recommendation of a friend. I was skeptical but it definitely makes a difference when it's switched on. I even noticed a difference when I changed the battery. |
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I also use foam that softens my beard and applies some kind of stuff for sensitive skin, and that makes a noticable difference too. |
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All of this makes shaving 10 times more expensive than it needs to be but I'm worth it. |
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Edit: Why would shaving foam be any better than rubbing something else into your face, like aftershave? |
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I kind of like the Halfbakedness, [Treon] - using low dose aspirin to lower danger from heart problems through shaving. |
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The things that I don't like are that i) you're treating the symptoms rather than the causes of heart disease, ii) you don't mention whether it comes in a 'Ladyshave' model, and iii) I'm not sure I want a blood thinning agent to be next to a razor blade. |
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Bah, I just figured out that coumadin is actually warfarin, and acetylsalicylic acid is more commonly known as aspirin! You don't make it easy for the rest of us do you? |
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aspirin protects from heart disease, coumadin does not. I am not sure if nonaspirin salicylates protect comparably well. Things like aspercreme are systemically absorbed and on can get salicylate toxicity from them. I am not sure one would get enough systemic absorbtion during the time shave cream remains on the face. |
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The idea of a topical salicylate cardioprotectant is a nifty one because it is very plausible. It would require a big head to head study against low dose aspirin but this is doable as well. |
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Bungston is right I had thought coumadin was widely effective against atherosclerosis but that isn't published; I found a study that supports transdermal acetylsalicylic acid at large doses; the amazingly teeny 1 mg to 200 microgram went better with that |
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a different drug 3,4-dehydro-cilostazol [link] might be effective at 2 or 3 mg; cilostazol is published as effective against atherosclerosis with lab animals; its looking like it might be effective at a ml or two (12 ml of dermal acetylsalicylic acid does things, but the divider on cilostazol is near 11) |
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another possibility is a modified fluorinated acetylsalicylic acid like diflunisal; diflunisal is about as good as acetylsalicylic acid at thrombic things lingers 3 or 4 times longer but might be tarted up to be more platelet active than acetylsalicylic acid; nitro-aspirins
create platelet active nitric oxide |
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a milliliter is a plausible amount of moisturizer or moisturizing Foundation; a possible womens topical route |
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My razor has six blades! I love the future! |
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adding a lovastatin workalike to foundation is of potentially vast benefit |
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For 5608 men and 997 postmenopausal women without clinical evidence of cardiovascular disease (CVD) who had average low-density lipoprotein cholesterol (LDL-C) and below average high-density lipoprotein cholesterol (HDL-C), 20-40 mg/day lovastatin reduced first acute major coronary events (AMCEs) 37% (for those receiving placebo and lovastatin, respectively, 183 and 116 first AMCEs defined as fatal or nonfatal myocardial infarction [MI], unstable angina, or sudden cardiac death; relative risk [RR] 0.63; 95% confidence interval [95% CI] 0.50, 0.79; p < 0.001). Statistically significant reductions in prespecified secondary end points (coronary revascularizations, unstable angina, MI, cardiovascular end point events, and coronary end point events) were also associated with lovastatin treatment in the overall cohort |
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An aspirin-glycolic peel, perhaps? |
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