CPP-peptide mosquito intoxicator

Getting rid of mosquitos assists in getting rid of Malaria, Which wikipedia says killed about 405,000 people in 2018.

1)putting mosquitos into such a deep sleep they starve or expire from dehydration with zeptogram doses of opiate peptides:

You can get an entire rat to fall asleep/get high with 700 picograms (700 trillionth of 1 gram) of a peptide that imitates opiates (an opiate peptide). Opiate peptides are published as working on insects. One possible statement of the dose of an opiate peptide to make a mosquito fall asleep so long it starves to death/dehyradtes too much to live is 1 millionth of the mass of a 1 nanogram rat dose. That is near a zeptogram or attogram per mosquito. so, kind of near 10^-18 grams as a mosquito dose.

At lower exposures the mosquito might just get disoriented, and be too intoxicated to figure out food-source sensing.

Another peptide, which is where this idea is new, is a custom peptide that disables CO2 sensing at mosquitos.

Mosquitos have CO2 and other chemoreceptors, I think this tactic works especially well with a certain kind of receptor, but it likely works on other types of receptors as well: It is published practice to make a peptide customized to Nestle-In to the nonreceptor tail of a GCPR and change the amount of receptivity of the receptor. It is possible to turn off the receptor this way.

A CO2 receptor tail nestling peptide that complements/attaches to the CO2 receptor is determined with software then screened as a library of variants to find one that works.

So, that is the new peptide, a tail-nestling peptide that turns off CO2 and one that turns off vision receptors at mosquitos. These peptides would be attached to CPP (cell penetrating peptides) for even more efficient dose potency.

Getting the mosquitos to land on the new, wet-style peptides :

New mosquito attractants have been found. As an object at the dwelling, a cheap surface like a cloth or tyvek-felt or as a window/screen spray the combination peptide-CPP + attractant would also be present and the zeptogram active dose would absorb through the mosquitos' feet

They can absorb through the mosquitos feet, because the mosquitos feet are standing on gel or moist cloth.

New to me is making an insecticide peptide or amino acid that is deliquescent (turn to puddle from water in the air). The cosmetic amino acid ingreadient NaPCA turns to a puddle of water when left out in the air. Putting some NaPCA amino acids on the opiate peptide/CO2-blocker/Vision blocker peptides causes them to be liquid, increasing their absorbability 2-16 times.

So CPP-NaPCA-active peptide is a possible very cheap linear structure, but they could also try it with the CPP and NaPCA on separate branched from the drug peptide. as Three branches on a +

The cost is miniscule. The octapeptide oxytocin is $40/Kg at alibaba, so if the full branched 19-24 amino acid is used it could be $480/Kq, enough to administer several quadrillion doses. Because the CPP-peptide dose is is so minute it has no effect if eaten by a human, it can (without NaPCA) be used as a printing ink, eventually making its way to be trash laying around the dwelling, new items at the dwelling, and Trash that in some locations is out of doors

With NaPCA the moist version could be on a purpose built mosquito terminating polymer film or object for less than 1/10th of a cent per sizeable polymer film object. Actually you might want to go for the polymer "pastry retrieval tissue" at the grocery as a model, I perceive these are 1/1000th of a cent or less. (A peel off sticker is 1/1000th of 1 cent)