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Um, what if the cancer isn't a leukaemia? |
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" At the moment, I am too lazy to research " |
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There doesn't appear to be any way Schistoma could
specifically be targeted at cancer cells. They don't interact
with cells at the level of genetic or cell surface markers
where cancerous cells are readily targeted. They don't have
any reason to preferentially target fast growing cells. |
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Therefore, [marked-for-deletion] bad science. |
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It seems as if the main cause of mortality with cancer is metastasis. True, those cells probably have distinctive markers, but if they metastasize through the blood, they're fair game. I also seem to remember that malignant tumours need steady blood supplies. |
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It also thrills me to report that there are more than 20,000 species of Trematoda. I wash my hands. |
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//I wash my hands.// Probably a good idea with all
those flukes about. |
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it's probably a whole lot easier to engineer some host
immune cells to react to a given marker than to engineer an
organism that is little used in science. Also, even if it works,
you'll have a whole load of blood flukes about, which are
going to be selected. Eventually one of them will get the
bright idea of reacting to a different antigen... then you
have a blood fluke problem. |
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"Well, Mrs. Spinkhorn, I have some good news and
some bad news. You're not going to die of
metastasizing colon cancer..." |
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And what [bs] said. Host immune cells have all the
necessary machinery and are made for the job. If we
could target flukes to attack cancer cells, we could
target the immune system more easily. |
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regarding cancerous cells that are not in the bloodstream,
it's no fluke that immune cells can worm their way into
tissue. |
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// if we removed their ability to reproduce, tied a filament around
them, so they'd eventually choke on their own obesity // |
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That would work on Americans, too ... |
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Needs more research [+] to be a halfbaked idea [-] |
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///it's probably a whole lot easier to engineer some host
immune cells to react to a given marker// 2014 |
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2017 Kymriah CAR-T is FDA approved, I'm in the wrong gig. If
someone could take care of all the tedious analysis and bench
work, I could devote more time to the ideas game. |
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// 2017 Kymriah CAR-T is FDA approved // |
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The list of side effects mirrors the dangers of early retirement... |
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//The list of side effects mirrors the dangers of early
retirement...// |
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Oh it's viscous. You're weaponizing your immune system
against yourself, your immune system will take out all cells
presenting the target antigens, which is supposed to be the
cancer cells, but it's not as specific as you'd like. |
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It makes no sense, except in the context of all the other
cancer therapies: cut/burn it out & poison. I recommend
Azra Raza on "The Drive" podcast E121, for a brutal
assessment of the current state of all things cancer. |
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I'm not abreast of the immunooncology world, but I imagine
they're looking at immunotherapy with an "off" switch. |
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