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An immunization that mimics exercise
exercise both upregulates and downregulates various chemicals circulating at the body. Immunizing against the ones it downregulates could confer some of the benefits of exercise ...without exercising | |
Exercise both up regulates and down regulates the
production of biochemicals at the body. It is possible
finding another way to reduce the chemicals that are
down
regulated could have some of the beneficial effects of
exercise.
One example is cholesterol. It is actually possible to
immunize
against cholesterol as well as down regulate it
with drugs. The idea then is to make a list of other
circulating biochemicals like proteins that go down with
exercise and then immunize against them. I will list
these
proteins when I find a better internet spot. One of them
is
some sort of myoglobin. And here they are: BACE1,
myocardial myoglobin, nitrite reductase, C/EBPβ, TNF-α.
Some of these might not be circulating proteins.
Of course an oral vaccine would be great, “here drink
this!
It’s 2/3 as good as exercising regularly and lasts your
whole
life!”
Immunizing with cholesterol causes rabbits to have 35% less cholesterol
https://www.ncbi.nl....gov/pubmed/8592095
Although the mean serum cholesterol level, mainly in the form of very-low-density lipoprotein cholesterol, rose as much as 60-fold in the nonimmunized rabbits, the elevation was significantly less--as much as 35% lower--in the immunized rabbits [beanangel, Dec 15 2017]
Immunizing rabbits with cholesterol reduces cholesterol plaques 74%
https://www.ncbi.nl....gov/pubmed/8696949
Immunization with LDL and oxidized LDL reduced atherosclerotic lesions in the proximal aorta by 74% (P < .05) and 48% (P = NS), respectively. [beanangel, Dec 15 2017]
nitrate reductase and myocardial myoglobin
https://www.ncbi.nl...gov/pubmed/23962643
Mice subjected to voluntary wheel running (VE) for 4weeks displayed an 18% reduction in infarct size when compared to sedentary mice, whereas mice administered nitrite therapy (25mg/L in drinking water) showed a 53% decrease. (interpreation: myocardial myoglobin causes the wrong kind of nitrate; so less is better) [beanangel, Dec 15 2017]
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Annotation:
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No, nature is cycles apon cycles apon cycles. Aiming for a constant action is only good for an emergency procedure. It would end up a poison. |
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//unicycles, bicycles or tricycles?//
With nature, all of the above and more. |
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[beany], can you reference the immunization against cholesterol? I don't see how it's possible, as cholesterol is a major component of cell membranes. |
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<edit> OK, I found articles about the immunization. It's actually against a protein involved in cholesterol processing, but I am surprised and impressed that it works! Thanks for bringing it to my attention. |
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[Ian] Or learning healthy hexacycle riding. |
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I put up a couple pubmed references where cholesterol, the
material, reduced cholesterol 35% and aortic lesions 74%. |
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I listed some proteins that go down with exercise as well, I
do not know if they are circulating proteins though: BACE1,
myocardial myoglobin, nitrite reductase, C/EBPβ, TNF-α |
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I would be very, very doubtful of letting anyone immunize me against myocardial myoglobin. |
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Yes, but would you try it on [beanangel] ? |
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Oh, obviously, but I've already put [8th]'s hand up to be first. |
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Rather than make a new junkie friend and then having
them
shoot me up with cholesterol liposomes there is another
option. |
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Have you noticed some jewelry leaves a green mark on
skin
from the copper? A gooey mess of copper and cholesterol
could be used to create an amulet that when worn causes
a
slight rash and immunizes against cardiovascular disease
with an external reaction |
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Let go of our wrist ... OW! LEGGO ! That HURTS ! That's not
funny ! We're NOT volunteering ! OUCH ! Let GO ! You are
going to get a right smack in a minute ... look, just make Sturton
try the stuff, it's not silver or garlic or holy water, it can't harm
him ... |
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1 ethel, 2,6 phenyl heptane looks like a bicycle. If it was 1
ethel, 2,6 ferrocene heptane it would have rotating wheels. |
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Well, if it looks like a bicycle, and it smells like a bicycle, and it
rides like a bicycle, it's probably a complex unsaturated
multicyclic hydrocarbon, without proper lights, brakes or a bell,
which means you can't ride it on a public road. |
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In the same way, you could delete a third of the attributes at
random from an application's object model, and expect it still to
be two thirds as useful. After all, it's not as if they interact, or
depend on each other, or anything. [-] |
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